Application Flexibility

The MultiSYNTH offers flexibility of operation.

Some examples of possible reactions are reported below.

Suzuki coupling reaction

N. E. Leadbeater and J. R. Schmink, Tetrahedron, 63, 2007, 6764.
Example of reaction optimized on a 3 mmol scale using the single-mode configuration and scaled up (5 and 10 mmol) using a parallel setup in the multimode configuration with a 99% yield in all the cases.

Synthesis of 2,3-disubstituted-quinazolin-4-ones (10 examples reported)

I. K. Kostakis, A. Elomri, E. Seguin, M. Iannelli and T. Besson, Tetrahedron Letters, 48, 2007, 6609
a) acetic anhydride, MW (200 W), 130 °C, 10 min.
b) CH₃NH₂ (2 equiv.), CH₂Cl₂, rt, 20 min.
c) formamide, MW (200 W), 170°C, 10 min.