Large Batch Scale-Up
Milestone has developed the BatchSYNTH for the scale-up of microwave-enhanced reactions.
In many scenarios, single reaction volumes of more than 100 ml are often required. Although these volumes and beyond can be processed using open glassware, there are many distinct advantages in performing reactions in closed vessels. These advantages derive from the possibility to operate at temperatures above the normal boiling point of the reaction mixtures and to safely accommodate the corresponding elevated vapor pressures.
Example of possible application
Dearomatization of pyridine-2-carboxylic acid
E. Heller, W. Lautenschläger, U. Holzgrabe, Tetrahedron Letters, 46, 2005, 1247.